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Mediators of Inflammation
Volume 2, Issue 6, Pages 443-446
http://dx.doi.org/10.1155/S0962935193000638
Research paper

Low molecular weight thymic factor inhibits histamine release from basophils

1R.E. Kavetsky Institute of Experimental Pathology, Onkology and Radiobiology, Acad. Sci. of Ukraine, ul. Vasilkovscaja 45, Kiev 252650, Ukraine
2Kiev Advanced Training Institute for Physicians, Clinical Immunology and Allergology Department, Dorogozshitskaya 9, Kiev 252112, Ukraine

Received 29 June 1993; Accepted 7 October 1993

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Low molecular weight thymic factor stimulates the suppressor function of T-lymphocytes, increases cAMP content (but not cGMP) in lymphocytes and inhibits histamine release from sensitized basophils. The mechanisms of LTF action are discussed.