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Mediators of Inflammation
Volume 2, Issue 4, Pages 317-322
http://dx.doi.org/10.1155/S0962935193000444
Research paper

Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice

Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET), Serrano 665, Buenos Aires 1414, Argentina

Received 6 April 1993; Accepted 25 May 1993

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H1 antagonist mepyramine and to the same extent by the phospholipase C inhibitor NCDC. By using a binding assay H1 histaminergic receptors were detected in autoimmune heart membrane preparations, but this was not observed in normal heart. These data suggest that autoimmune myocardium expressed a functional H1 receptor that could involve a distinctive mechanism operating in the disease.