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Mediators of Inflammation
Volume 2, Issue 6, Pages 429-433
http://dx.doi.org/10.1155/S0962935193000614
Research paper

Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture

1Mario Negri Institute for Pharmacological Research, via Gavazzeni 11, Bergamo, Italy
2Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo 24125, Italy

Received 26 July 1993; Accepted 20 September 1993

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.