Abstract
Activated polymorphonuclear leucocytes, which are accumulated in
inflammatory lesions of inflammatory bowel disease, produce tissue
destructive, oxygen derived free radicals and other inflammatory
mediators. The PMN superoxide production elicited by
formyl-methionyl-leucyl-phenylalanine or the complement split
product 5a were compared in IBD and healthy volunteers.
Significantly reduced superoxide production was found in PMNs from
patients with Crohn's disease as compared to normal controls,
when fMLP or CSa were used as stimulants (