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Mediators of Inflammation
Volume 3, Issue 1, Pages 3-9
Invited review

The Role of Cytokines in Inflammatory Bowel Disease

Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK

Received 30 November 1993; Accepted 30 November 1993

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cytokines play an important role in the development and persistence of the inflammatory lesions seen in Crohn's disease and ulcerative colitis. This review discusses the current thinking of the role of cytokines in chronic intestinal inflammation including the involvement of immunoregulatory cytokines within the Th1 and Th2 subsets.