Abstract
E-selectin (CD62E) is an endothelial specific glycoprotein belonging
to the selectin family of adhesion molecules. Because a high
expression of this molecule at intestinal mucosal surfaces in
inflammatory bowel disease (IBD) has been described earlier, the aim
was to assess serum levels of E-selectin (sE-selectin) and to
correlate it to disease activity, and further to evaluate its
chemotactic properties at physiological concentrations. Levels of
sEselectin were measured by a sandwich ELISA technique in 31 IBD
patients together with 15 healthy volunteers. In ulcerative colitis
the median value was 0.46 nM (0.16–0.75), in Crohn’s disease
0.47 nM (0.22–1.24), and in healthy controls 0.34 nM
(0.22–0.83). No statistically significant differences in
sE-selectin were revealed between these groups (