Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 3, Issue 1, Pages 57-60

Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous Meningitis

Institute of Infectious Diseases, University ‘La Sapienza’, Policlinico Umberto I, Viale Regina Elena 331, Rome 00161, Italy

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The local production of tumour necrosis factor-α (TNFα) was evaluated in the cerebrospinal fluid (CSF) from ten patients with tuberculous meningitis (TBM). The degree of intrathecal immune activation was also studied by assessing the CSF levels of β2-microglobulin (β2-M) and adenosine deaminase activity (ADA). Results indicate that elevated CSF concentrations of TNFα, β2-M and ADA were found in all TBM patients. Moreover, TNFα is produced and selectively concentrated for a long period of time, while β2-M and ADA values progressively decline during the course of TBM. Our findings suggest that in TBM patients, after an early activation of immune cells, there is an enhanced and continuous production of TNFα at the site of infection.