Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 5, Issue 4, Pages 295-298
http://dx.doi.org/10.1155/S0962935196000439

Syntheses of two deacetyl-thymosin α1 analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients

Kidney Research Laboratory, Kojinkai, 1-6, Tsutsujigaoka 2-chome, Miyagino-ku, Sendal 980, Japan

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two deacetyl-thymosin α1 analogues containing Phe (4Br) or D-Phe (4Br) residue—[D-Phe(4Br)21]deacetyl-thymosin α1 and [Phe(4Br)21]deacetyl-thymosin α1, respectively—were synthesized by the manual solid-phase method and their immunological effects on the low E-rosette-forming lymphocytes of uraemic patients were examined. One of the synthetic analogues, [Phe(4Br)21deacetyl-thymosin α1, demonstrated a restorative effect on the low E-rosette-forming lymphocytes of uraemic patients, which was stronger than that of deacetyl-thymosin α1, but the other analogue, [D-Phe(4Br)21]deacetyl-thymosin α1, showed no restorative effect under the same conditions.