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Mediators of Inflammation
Volume 6 (1997), Issue 1, Pages 73-74
http://dx.doi.org/10.1080/09629359791974

Systemic inflammatory response syndrome (SIRS) induced by carbon tetrachloride in rats

1Department of Pharmacology, University Medical School, Debrecen, Debrecen H-4012, Hungary
2III. Medical Clinic, University Medical School, Debrecen, Debrecen H-4012, Hungary
3II. Medical Clinic, University Medical School, Debrecen, Debrecen H-4012, Hungary

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We have observed the symptoms of systemic inflammatory response syndrome (SIRS) in male rats intoxicated by carbon tetrachloride (CCl4). Severe hypothermia, tachypnoea and increase in the heart beat min were diagnosed. These symptoms developed in the first hour of intoxication. The hepatic dysfunction was characterized by elevated bilirubin levels. In the sera we have measured increases in the activity of secretable (group II) phospholipase A2 sPLA2 (2,8x) and 6-ketoprostaglandin F (KPGF) (1,44x). Supposedly the free radicals derived from CCl4—mainly trichloromethyl—could induce the prompt reaction of SIRS and the release of sPLA2 as well as the formation of KPGF. Our findings show that in the early phase of CCl4 intoxication the symptoms of SIRS can be related to elevation of sPLA2 and the products of cyclooxygenase II.