Mediators of Inflammation

Mediators of Inflammation / 1997 / Article

Open Access

Volume 6 |Article ID 509085 | https://doi.org/10.1080/09629359791758

P. Vergne, V. Praloran, R. Treves, Y. Denizot, "Decreased levels of serum platelet-activating factor acetylhydrolase in patients with rheumatic diseases", Mediators of Inflammation, vol. 6, Article ID 509085, 2 pages, 1997. https://doi.org/10.1080/09629359791758

Decreased levels of serum platelet-activating factor acetylhydrolase in patients with rheumatic diseases

Abstract

PAF is a potent inflammatory compound known to stimulate the release of various cytokines involved in rheumatic diseases. Elevated blood PAF levels are reported in these patients. We report that serum PAF acetylhydrolase activity (AHA) levels are decreased in patients with rheumatoid arthritis or osteoarthritis as compared to healthy controls. Serum and synovial fluid AHA levels were correlated in these patients. The present study suggests the potential role of AHA in controling systemic and/or local PAF levels in patients with rheumatic diseases.

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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