Mediators of Inflammation

Mediators of Inflammation / 1997 / Article

Open Access

Volume 6 |Article ID 562129 |

A. Van Der Meeren, J.-M. Bertho, M. Vandamme, M.-H. Gaugler, "Ionizing radiation enhances IL-6 and IL-8 production by human endothelial cells", Mediators of Inflammation, vol. 6, Article ID 562129, 9 pages, 1997.

Ionizing radiation enhances IL-6 and IL-8 production by human endothelial cells


Irradiation exposure is known to induce an inflammatory reaction. Endothelial cells play a crucial role both in the inflammatory process and in radiation damage. Therefore, supernatants and cell lysates of 60Co-irradiated human umbilical vein endothelial cells (HUVEC) have been assessed for the presence of pro-inflammatory cytokines. After gamma irradiation, interleukin (IL)-1α, IL-1β and tumor necrosis factor (TNF)-α remained undetectable in both cell supernatants and cell lysates. However, a dose-dependent increase in the production of IL-6 and IL-8 has been demonstrated up to 6 days after exposure. These data indicate that the pro-inflammatory cytokines IL-6 and IL-8 may be involved in the inflammatory response of vascular endothelium induced by exposure to ionizing radiation.

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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