Mediators of Inflammation

Mediators of Inflammation / 1997 / Article

Open Access

Volume 6 |Article ID 602738 | https://doi.org/10.1080/09629359791956

T. Abiko, H. Sekino, "Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes", Mediators of Inflammation, vol. 6, Article ID 602738, 5 pages, 1997. https://doi.org/10.1080/09629359791956

Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes

Abstract

Phe12 of deacetyl-thymosin β4 is one of the structural essentials for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. In order to evaluate the functional roles of this phenyl group in the restorative effect on impaired T-lymphocytes, two analogues, [1- Nal12]deacetyl-thymosin β4 and [Cha12]deacetyl4 thymosin β4, were synthesized by a solid-phase method and evaluated for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. The results indicated that [1-Nal12]deacetyl-thymosin β4 which had a bulky naphthyl ring showed a stronger restorative effect than that of deacetyl-thymosin β4, but it was slightly weaker than that of [Phe(4F)12]deacetyl-thymosin β4. However, [Cha12]deacetyl-thymosin β4 showed no restorative effect on the impaired blastogenic response of uraemic T-lymphocytes.

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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