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Mediators of Inflammation
Volume 6, Issue 5-6, Pages 323-326
http://dx.doi.org/10.1080/09629359791451

Pulmonary hypertension in infants with congenital heart defects: are leukotrienes involved?

1Service de Chirurgie et Réanimation Cardiaques Pédiatriques, Centre Chirurgical Marie-Lannelongue, 133, avenue de la Résistance, Le Plessis-Robinson, 92350, France
2CNRS ERS 566, Centre Chirurgical Marie-Lannelongue, 133, avenue de la Résistance, Le Plessis-Robinson, 92350, USA

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The circulating levels of leukotriene E4 in infants with congenital heart defects, increased pulmonary blood flow and pulmonary arterial hypertension, were determined and compared with infants with decreased pulmonary blood flow (Tetralogy of Fallot). There was no correlation (r=0.38) between the pulmonary arterial pressure (56 ± 4 mmHg) and the leukotriene E4 levels (1.37 ± 0.67 ng/ml blood) measured in peripheral blood samples from the hypertensive group prior to surgery. There was considerable variation in the detectable leukotriene E4 levels in blood samples from different patients. The levels detected in the blood samples between the two groups of patients was similar. These data suggest that neither the surgical repair during cardiopulmonary bypass nor the pulmonary hypertension appeared to modify the leukotriene E4 blood levels in the small number of patients studied.