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Mediators of Inflammation
Volume 6, Issue 1, Pages 39-45
http://dx.doi.org/10.1080/09629359791910

Lung eicosanoids in perinatal rats with congenital diaphragmatic hernia

1Department of Paediatric Surgery, Division of Respiratory Medicine, Erasmus University Rotterdam and University Hospital/Sophia Children's Hospital, Dr. Molewaterplein 60, Rotterdam 3015 GJ, The Netherlands
2Department of Paediatrics, Division of Respiratory Medicine, Erasmus University Rotterdam and University Hospital/Sophia Children's Hospital, Dr. Molewaterplein 60, Rotterdam 3015 GJ, The Netherlands
3Department of Pharmacology, Erasmus University Rotterdam and University Hospital/Sophia Children's Hospital, Dr. Molewaterplein 60, Rotterdam 3015 GJ, The Netherlands

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Abnormal levels of pulmonary eicosanoids have been reported in infants with persistent pulmonary hypertension (PPH) and congenital diaphragmatic hernia (CDH). We hypothesized that a dysbalance of vasoconstrictive and vasodilatory eicosanoids is involved in PPH in CDH patients. The levels of several eicosanoids in lung homogenates and in bronchoalveolar lavage fluid of controls and rats with CDH were measured after caesarean section or spontaneous birth. In controls the concentration of the stable metabolite of prostacyclin (6-keto-PGF), thromboxane A2 (TxB2), prostaglandin E2 (PGE2), and leukotriene B4 (LTB4) decreased after spontaneous birth. CDH pups showed respiratory insufficiency directly after birth. Their lungs had higher levels of 6- keto-PGF, reflecting the pulmonary vasodilator prostacyclin (PGI2), than those of controls. We conclude that in CDH abnormal lung eicosanoid levels are present perinatally. The elevated levels of 6-keto-PGF in CDH may reflect a compensation mechanism for increased vascular resistance.