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Mediators of Inflammation
Volume 7 (1998), Issue 2, Pages 105-110
http://dx.doi.org/10.1080/09629359891252

(1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen

1Department of Environmental Medicine, University of Gothenburg, Box 414, Gothenburg 40530, Sweden
2Western Australian Research Institute for Child Health, Princess Margaret Hospital for Children, Subiaco, Western Australia, Australia

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Exposure to dust may involve co-exposure to agents which are allergens, together with those which are pro-inflamm atory. To study the effects of such a coexposure, the humoral and inflammatory responses were studied in guinea pigs inhaling the T-cell dependent antigen ovalbumin (OVA) and the inflammatory agents (13)-β -D-glucan and lipopolysaccharide (LPS). The effects were evaluated as inflammatory cells in the lung and serum antibodies to OVA. LPS caused a stimulation of the OVA-induced antibody production which was abolished by simultaneous exposure to (13)-β-D-glucan. An increase of eosinophils after OVA exposure was decreased by coexposure to (13)-β-D-glucan. The results demonstrate a complex interaction between adaptive and innate immune mechanisms in the lung, determined by exposure to common contaminants in airborne dust.