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Mediators of Inflammation
Volume 9, Issue 3-4, Pages 201-206

Synthesis of [l-Nal3] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes

Research Laboratory, Global Shinwa Pharmaceutical Co. Ltd, 2–546–1, Yoriki, Matsuomura, Iwate-gun, Iwate-ken, 028–7302, Japan

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A TP II analogue, [l-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [l-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impaired T-lymphocyte transformation by PHA in uremic patients suffering from recurrent infectious diseases. The synthetic analogue was found to have stronger restorative activity than those of our synthetic TP II and [Phe (4 F)3] TP II.