Synthesis of [l-Nal³] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes

Abstract

A TP II analogue, [l-Nal³] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me₂Se and m-cresol as scavengers. The synthetic [l-Nal³] TP II, TP II and [Phe (4 F)³] TP II were tested for comparative effect on the impaired T-lymphocyte transformation by PHA in uremic patients suffering from recurrent infectious diseases. The synthetic analogue was found to have stronger restorative activity than those of our synthetic TP II and [Phe (4 F)³] TP II.