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Mediators of Inflammation
Volume 9 (2000), Issue 3-4, Pages 133-140
http://dx.doi.org/10.1080/09629350020003858

Soluble form of ICAM-1, VCAM-1, E- and L-selectin in human milk

1Hormone Laboratory, Athens University, Aretaieion University Hospital, 76 Vas. Sophias Ave., Athens GR-115 28, Greece
2Neonatal Unit of the 2nd Department of Obstetrics and Gynecology, Athens University, Aretaieion University Hospital, 76 Vas. Sophias Ave., Athens GR-115 28, Greece
3the 2nd Department of Obstetrics and Gynecology, Athens University, Aretaieion University Hospital, 76 Vas. Sophias Ave., Athens GR-115 28, Greece

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In breast milk and paired serum from 70 lactating women and 40 of their term, infection-free neonates, on the 2nd and 5th day postpartum slCAM-1, sVCAM-1, sE- and sL-selectin were measured by ELISA and compared with those in 26 healthy adults (controls). Seven infant formulas and fresh milk from five cows were also analyzed. Human colostrum values of slCAM-1, sVCAM-1 (similar to those in maternal and control serum), sE-selectin and sL-selectin (˜10 and ˜100 times lower than in maternal and control serum) were significantly higher than those in milk, while they varied widely. None of the adhesion molecules was detected in fresh cow’s milk or infant formulas. Exclusively breast-fed infants showed significantly higher values of slCAM-1 and sL-selectin on the 2nd day of life than those supplemented also with formula. Only slCAM-1 values correlated positively between colostrum and time-matched maternal serum. These findings show in human milk important amounts of slCAM-1 and sVCAM-1 but minimal amounts of sE- and sL-selectin, which could affect the immune system of the neonate.