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Mediators of Inflammation
Volume 11 (2002), Issue 6, Pages 345-349
http://dx.doi.org/10.1080/0962935021000051539

Tumour necrosis factor-α, interleukin-2 soluble receptor and different inflammatory parameters in patients with rheumatoid arthritis

1Department of Clinical Analysis, Center of Healthy Sciences, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, Florianópolis 88040–970, SC, Brazil
2Laboratório Médico Santa Luzia, Center of Biological Sciences, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, Florianópolis 88040–970, SC, Brazil
3Department of Pharmacology, Center of Biological Sciences, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, Florianópolis 88040–970, SC, Brazil

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and aims: Although the participation of cytokines in the pathogenesis of rheumatoid arthritis (RA) seems to be unequivocal, their relationship with current serum markers of this disease is not clear. The present study analyses whether there is any correlation between the levels of tumour necrosis factor-α (TNF-α), interlukin-2 soluble receptor (sIL-2R) and the concentrations of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and β2-microglobulin in a group of 21 patients with RA, all rheumatoid factor positive.

Methods: The levels of TNF-α and sIL-2R were analysed in association with other parameters of inflammation (ESR, CRP and β2-microglobulin).

Results: In comparison with the control group, RA patients presented high median levels of both cytokines, TNF-α (6.4 pg/ml) and sIL-2R (56 pmol/L), as well as of ESR (34 mm/h), CRP (0.9 mg/dl) and β2-microglobulin (1.6 mg/dl) (p<0.01). However, only ESR levels in the RA group significantly differ from the control group (p<0.01). No correlation was found between the inflammatory parameters.

Conclusions: These results suggested that TNF-α and slL-2R levels are up-regulated in RA patients but did not significantly differ from the control group. Due to the chronic course of this disease, other inflammatory markers must be identified in order to provide early therapeutic strategies to these patients.