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Mediators of Inflammation
Volume 11 (2002), Issue 4, Pages 261-263
http://dx.doi.org/10.1080/096293502900000122

The effect of high dose digoxin on cytokines in healthy dogs

1Department of Biochemistry, School of Medicine, University of Yüzüncü Yil, YüzüncüYil Üniversitesi, Tip Fakültesi, Biyokimya Anabilim Dali, Maraş Caddesi, Van 65300, Turkey
2Department of Cardiology, School of Medicine, University of Yüzüncü Yil, YüzüncüYil Üniversitesi, Tip Fakültesi, Biyokimya Anabilim Dali, Maraş Caddesi, Van 65300, Turkey
3Department of Internal Medicine, School of Medicine, University of Yüzüncü Yil, YüzüncüYil Üniversitesi, Tip Fakültesi, Biyokimya Anabilim Dali, Maraş Caddesi, Van 65300, Turkey

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Tumor necrosis factor (TNF)-α and interleukin (IL)-1β are pro-inflammatory cytokines, causing myocardial dysfunction and a negative inotropic effect. The drugs used to treat heart failure affect the production of cytokines. Digoxin, on which this study was focused, is one of the drugs for the treatment of heart failure.

Aim: The present study was designed to examine the early effects of high doses of digoxin on the production of cytokines in healthy dogs.

Methods: Digoxin was given parenterally to dogs at 0.15 mg/kg. IL-1β and TNF-α production and levels of digoxin in the serum were measured 0, 12, 24, 48, and 72 h following administration of digoxin.

Results: As the levels of serum digoxin taken at 12, 24, 48, and 72 h of administration were considered significantly high compared with preceding values (p<0.001), no notable change in serum IL-1β and TNF-α levels was observed.

Conclusions: These results suggest that high doses of digoxin do not cause a significant cytokine production in heart muscle in the early phase.