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Mediators of Inflammation
Volume 12, Issue 1, Pages 9-14
http://dx.doi.org/10.1080/0962935031000096926

Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis

1Department of Pulmonary Medicine, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, Turkey
2Department of Pulmonary Medicine, Faculty of Medicine, Erciyes University, Turkey
3Department of Immunology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, Turkey

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-α, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-α, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray (minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-α (20.9±10/15.4±8 pg/ml) and sIL-2R (2569±842/1444±514 pg/ml) were statistically different between patients and controls (p=0.02 and p=0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-α and sIL-2R (r=0.34), but there was no correlation between IL-4 and TNF-α, and between IL-4 and sIL-2R (r=0.23 and r=0.22). The TNF-α level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-α, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity.