Mediators of Inflammation

Mediators of Inflammation / 2004 / Article

Open Access

Volume 13 |Article ID 132347 |

Byoung Chul Kim, Tae-Jin Kang, Song Hou Jin, Se-Kon Kim, Seong-Boem Lee, Gue-Tae Chae, "Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice", Mediators of Inflammation, vol. 13, Article ID 132347, 2 pages, 2004.

Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice

Received17 Oct 2003
Accepted27 Oct 2003


RIPK 2 is adapter molecule in the signal pathway involved in Toll-like receptors. However, there has been no reported association between receptor-interacting serine/threonine kinase 2 (RIPK 2) expression and the infectious diseases involving mycobacterial infection. This study found that its expression was down-regulated in the footpads and skin but was up-regulated in the liver of Mycobacterium leprae-infected nu/nu mice compared with those of the M. leprae non-infected nu/nu mice. It was observed that the interlukin-12p40 and interferon-γ genes involved in the susceptibility of M. leprae were down-regulated in the skin but were up-regulated in the liver. Overall, this suggests that regulation of RIPK 2 expression is tissue-specifically associated with M. leprae infection.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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