Mediators of Inflammation

Mediators of Inflammation / 2004 / Article

Open Access

Volume 13 |Article ID 321035 |

F. Morabito, M. Cristani, A. Saija, C. Stelitano, V. Callea, A. Tomaino, P. L. Minciullo, S. Gangemi, "Lipid peroxidation and protein oxidation in patients affected by Hodgkin's lymphoma", Mediators of Inflammation, vol. 13, Article ID 321035, 3 pages, 2004.

Lipid peroxidation and protein oxidation in patients affected by Hodgkin's lymphoma


A dysregulation of the redox homoeostasis has been reported in various neoplastic disorders. Malondialdehyde/4-hydroxy-2,3-nonenal (MDA/HNE) and protein carbonyl groups represent in vivo indexes of lipid peroxidation and protein oxidation, respectively, suitable to investigate radical-mediated physio-pathological conditions.We evaluated MDA/HNE and protein carbonyl groups in sera of untreated Hodgkin's lymphoma (HL) patients in advanced disease stages, in order to quantify the oxidative stress.HL patients displayed significantly higher levels of both MDA/HNE and protein carbonyl groups as compared with healthy controls.This is the first evidence that a strong increase in HL is one of the most common haematological malignancies, representing approximately 30% of all lymphomas in the circulating protein carbonyl content in HL. These findings may contribute to a better definition of the redox homoeostasis dysregulation in HL.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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