Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 13, Issue 4, Pages 269-273
http://dx.doi.org/10.1080/09629350400003084

Serum procalcitonin and cerebrospinal fluid cytokines level in children with meningitis

1Department of Pediatrics, Medical Faculty of Firat University, Elazig, Turkey
2Department of Immunology, Medical Faculty of Firat University, Elazig, Turkey

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims: To determine the level of serum procalcitonin and cerebrospinal fluid cytokines in children with bacterial or viral meningitis and to document the use of these parameters in differential diagnosis.

Results: Before the start of antibiotic treatment, serum procalcitonin and tumor necrosis factor alpha levels were found to be higher in acute bacterial meningitis compared with viral meningitis and with the control group. Similarly, cerebrospinal fluid interleukin-6 levels were found to be significantly higher in children with acute bacterial meningitis compared with viral meningitis. However, no significant difference was determined between groups in respect to the cerebrospinal fluid interleukin-8 level.

Conclusion: Serum procalcitonin and cerebrospinal fluid tumor necrosis factor alpha levels can be used in the early diagnosis of bacterial meningitis. Similarly, they may be useful adjuncts in differential diagnosis of bacterial and viral meningitis.