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Mediators of Inflammation
Volume 13, Issue 1, Pages 21-24

Suppression of neutrophil recruitment in mice by geranium essential oil

1Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192-0395, Japan
2Department of Bioengineering, Faculty of Technology, Teikyo University, 1-1, Toyosato-dai, Utsunomiya, Tochigi 320-0003, Japan

Received 24 October 2003; Accepted 6 November 2003

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited.

Aims of the study: To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo.

Method: The effect of essential oils on leukocyte and neutrophil recruitment induced 6 h after intraperitoneal injection of casein in mice was examined.

Results: Leukocyte recruitment into the peritoneal cavity in mice was suppressed by intraperitoneal injections of geranium, lemongrass and spearmint oils at the dose of 5 μl/mouse, but was not by tea tree oil. This recruitment was inhibited dose-dependently by geranium oil. The suppression of leukocyte recruitment resulted from inhibition of neutrophil accumulation.

Conclusion: Some essential oils used as anti-inflammatory remedies suppress neutrophil recruitment into the peritoneal cavity in mice.