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Mediators of Inflammation
Volume 13, Issue 3, Pages 195-199

Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma

1Department of Internal Medicine, Pneumonology and Allergology, Military Institute of Medicine, 128 Szaserów Street, Warsaw 00-909, Poland
2National Influenza Center, National Institute of Hygiene, Warsaw, Poland

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


BACKGROUND: One of the most promising markers of allergic inflammation is eotaxin, which has a selective influence on the migration of eosinophils. Its serum content significantly correlates with the intensity of allergic symptoms, so it might be interesting to know whether vaccination has any influence on serum expression of this chemokine.

Aims: Comparison of the humoral response to influenza vaccine and post-vaccination changes in the serum eotaxin level in patients with allergic bronchial asthma and healthy controls.

Methods: Forty-two asthmatics and 45 healthy individuals were vaccinated with a single dose of influenza subunit vaccine (Influvac). The serum eotaxin level and the antibody response to haemagglutinin (HI) and neuraminidase (NI) glycoproteins were measured before and after vaccination.

Results: A significant increase of geometric mean titres of HI and NI was observed in both groups. There were no significant differences between the groups in meanfold increase of HI and NI titres, response rate and protective level of HI. After vaccination, a significant decrease of the mean serum eotaxin value was observed in patients with asthma (149.4±71.0 versus 125.1±67.0, p=0.0017), while no similar effect was present in healthy individuals (153.4±56.9 versus 159.3±54.4, p=0.5).

Conclusions: The results indicate that in patients with allergic bronchial asthma influenza vaccinations assure efficient protective antibody level and modulate the serum level of eotaxin.