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Mediators of Inflammation
Volume 2005, Issue 3, Pages 180-183

Proinflammatory Cytokines and Leptin Are Increased in Serum of Prepubertal Obese Children

1Department of Pediatrics, Medical Faculty, Firat University, Elazig, 23119, Turkey
2Department of Biochemistry, Medical Faculty, Firat University, Elazig, 23119, Turkey

Received 20 January 2005; Accepted 21 February 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It has not yet been shown in prepubertal children how cytokines, leptin, and body mass, as well as parameters of obesity are interrelated. The aim of this study was to explore the relation between circulating levels of some cytokines with leptin and body mass index. A case control study was carried out in obese children of both sexes. An obese group was carried out with 63 school prepubertal children and a control group comprised the same number of nonobese children paired by age and by sex. Mean serum leptin concentration was significantly higher in the obese children at 19.9±7.4 ng/mL, than the control group (7.9±5.1 ng/mL). Serum IL-1β, IL-6, and TNF-α levels were also significantly higher in the obese group than controls (33.0±8.9, 45.2±11.8, and 9.2±2.3 pg/mL, versus 3.6±1.0, 13.1±3.9, and 3.9±1.0 pg/mL, resp). In controversy, serum IL-2 level was diminished in the obese group as 0.4±0.1 versus 0.9±0.1 U/L. Obesity may be a low-grade systemic inflammatory disease. Obese prepubertal children have elevated serum levels of IL-1β, IL-6, and TNF-α which are known as markers of inflammation.