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Mediators of Inflammation
Volume 2005 (2005), Issue 1, Pages 57-59
http://dx.doi.org/10.1155/MI.2005.57

Levels of Malondialdehyde and Superoxide Dismutase in Subclinical Hyperthyroidism

1Department of Internal Medicine, Medical Faculty, Sutcu Imam University, Kahramanmaras 46060, Turkey
2Department of Biochemistry, Medical Faculty, Sutcu Imam University, Kahramanmaras 46060, Turkey
3Department of General Surgery, Medical Faculty, Sutcu Imam University, Kahramanmaras 46060, Turkey

Received 9 November 2004; Accepted 25 November 2004

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We aimed to determine whether patients with subclinical hyperthyroidism (SH) are subject to oxidative stress. Twenty-two women and 8 men having endogenous subclinical hyperthyroidism for a duration of at least 6 months, and 21 women and 9 men healthy controls were included in this study. We measured the level of plasma malondialdehyde, as one of the lipid peroxidation markers, and the activity of erythrocyte superoxide dismutase, which is an antioxidant enzyme. The activity of erythrocyte superoxide dismutase and plasma malondialdehyde levels were found to be significantly higher in subjects with subclinical hyperthyroidism than the control group (P<.01). The results of this study suggest that oxidative stress and antioxidative response could be increased in patients having subclinical hyperthyroidism.