Mediators of Inflammation

Mediators of Inflammation / 2005 / Article

Open Access

Volume 2005 |Article ID 578408 |

Joanna Narbutt, Aleksandra Lesiak, Malgorzata Skibinska, Anna Wozniacka, Anna Sysa-Jedrzejowska, Joalanta Lukamowicz, Henk van Loveren, "Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans", Mediators of Inflammation, vol. 2005, Article ID 578408, 6 pages, 2005.

Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans

Received06 Apr 2005
Accepted06 Jun 2005


The aim of our study was to compare serum concentration of IL-1β, IL-6, IL-8, IL-10, and TNF-α in 105 healthy volunteers before and after exposure to UVR: 25 subjects (10 days of UVB), 55 (10 days of UVB or solar-simulated radiation, followed by acute UVB dose), and 25 (local high dose of UVB). In all the individuals blood samples were analyzed before and after final irradiation by chemiluminescence assay. After 10 days of UVB irradiation a statistically significant increase in serum concentration only in IL-8 (P<.05) and strong tendency in TNF-α(P=.05) were observed. The applied schedules of irradiation have minor impact on serum cytokine level and still a threshold dose of UVR causing systemic immune impairment is unknown.

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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