The aim of our study was to compare serum concentration of
IL-1β, IL-6, IL-8, IL-10, and TNF-α in 105
healthy volunteers before and after exposure to UVR: 25 subjects
(10 days of UVB), 55 (10 days of UVB or solar-simulated radiation,
followed by acute UVB dose), and 25 (local high dose of UVB). In
all the individuals blood samples were analyzed before and after
final irradiation by chemiluminescence assay. After 10 days of UVB
irradiation a statistically significant increase in serum
concentration only in IL-8 (P<.05) and strong tendency in
TNF-α(P=.05) were observed. The applied
schedules of irradiation have minor impact on serum cytokine level
and still a threshold dose of UVR causing systemic immune
impairment is unknown.