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Mediators of Inflammation
Volume 2005 (2005), Issue 3, Pages 121-130
http://dx.doi.org/10.1155/MI.2005.121

On the Role of sIL-2R Measurements in Rheumatoid Arthritis and Cancers

Department of Food Commodities Science and Technology, Medical University of Bialystok, Kilinskiego 1, Bialystok 15-089, Poland

Received 8 March 2005; Accepted 11 April 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A soluble IL-2 receptor (sIL-2R) is a circulating form of a membrane receptor localized on lymphoid and some cancer cells. The biological function of sIL-2R has not been completely understood. Substantially, it seems to reflect T-lymphocyte activation in diseases of different pathology. Moreover, the soluble receptor has been considered, at least in part, responsible for unsuccessful immunotherapy with IL-2 in cancers. Several lines of evidence indicate sIL-2R measurements to be useful in determining disease progress and prognosis. This review summarizes current knowledge on the sIL-2R behavior in RA and solid cancers of varied etiology.