Mediators of Inflammation
Volume 2005 (2005), Issue 4, Pages 202-209
http://dx.doi.org/10.1155/MI.2005.202
Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of TH 1 to TH 2 Phenotypes During Disease Progression
1Key Laboratory of Animal Resistance Research, College of Life Sciences, Shandong Normal University, Jinan 250014, China
2Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University, Wageningen, The Netherlands
Received 11 April 2005; Accepted 23 May 2005
Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Macrophages (Mp) are implicated in both early and late phases in type 1 diabetes development. Recent study has suggested that a balance between reductive Mp (RMp) and oxidative Mp (OMp) is possible to regulate T