Concentrations of acute phase proteins (CRP: C-reactive protein,
albumin) change during surgery. We investigated the acute phase
response to circumcision and the effects of anaesthesia on this
response. The children were divided into four groups; group 1
(intratracheal general anaesthesia, n=40), group 2 (general
anaesthesia with mask, n=20), group 3 (ketamine, n=20), group
4 (local anaesthesia, n=35). Blood samples were obtained, 24
hours before circumcision, after premedication, and 24 hours after
circumcision. CRP and albumin before circumcision were comparable
for all groups. There was no increase in CRP, and albumin remained
steady throughout the study. No difference was observed among the
groups, and related to anaesthesia. No responsiveness may be
explained with the size of injured tissue or anatomical and
histological type of preputium.
