ApoE Polymorphism Is Associated With C-Reactive Protein in
       Low-HDL Family Members and in Normolipidemic Subjects

Kahri, Juhani; Soro-Paavonen, Aino; Ehnholm, Christian; Taskinen, Marja-Riitta

doi:https://doi.org/10.1155/MI/2006/12587

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 012587 | https://doi.org/10.1155/MI/2006/12587

ApoE Polymorphism Is Associated With C-Reactive Protein in Low-HDL Family Members and in Normolipidemic Subjects

Juhani Kahri,¹Aino Soro-Paavonen,^1,2Christian Ehnholm,³and Marja-Riitta Taskinen¹

Received30 Dec 2005

Revised15 Mar 2006

Accepted20 Mar 2006

Published27 Apr 2006

Abstract

The study was aimed to compare inflammatory parameters between carriers of apoE4 isoforms (apoE4/3, apoE4/2, and apoE4/4 phenotypes) and those of carrying apoE3 isoform without apoE4 isoform (apoE3/3 phenotypes and apoE2/3 phenotypes). The concentrations of serum hsCRP, sVCAM-1, sICAM-1, and sE-selectin were measured in 211 subjects from Finnish low-HDL families and in 157 normolipidemic subjects. The subjects with apoE4 isoform had lower concentrations of serum hsCRP both in low-HDL family members (p<0.05) and in normolipidemic subjects (p<0.01). The differences in serum CRP values remained significant after adjustment for age, BMI, smoking status, hypertension, gender, lipoprotein variables, and family number. We conclude that apoE phenotype has a strong influence on serum CRP values.

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Copyright © 2006 Juhani Kahri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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