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Mediators of Inflammation
Volume 2006, Article ID 16043, 5 pages
Research Communication

Nitric Oxide Levels in Patients with Psoriasis Treated with Methotrexate

1Department of Dermatology, Medical Faculty, Zonguldak Karaelmas University, Zonguldak 67600, Turkey
2Department of Dermatology, Medical Faculty, Gazi University, Ankara 06100, Turkey
3Department of Biochemistry, Medical Faculty, Gazi University, Ankara 06100, Turkey
4Department of Dermatology, Medical Faculty, Yeditepe University, Istanbul 34100, Turkey

Received 13 February 2006; Revised 14 March 2006; Accepted 16 March 2006

Copyright © 2006 Nilgun Solak Tekin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Psoriasis is a chronic, recurrent, inflammatory, and hyperproliferative disease. Recently there have been studies regarding increases in the levels of NO in inflammatory dermatoses including psoriasis. In this study, 22 patients with psoriasis were scored with PASI (psoriasis area and severity index) and the levels of serum nitrite-nitrate were evaluated before and after therapy with methotrexate (Mtx). The results were compared with age- and sex-matched healthy volunteers. The relation of the results with the clinical severity and the cumulative Mtx dose were also evaluated. The serum levels of nitrite-nitrate of the psoriatic patients with active lesions were found to be significantly higher than the levels of the healthy volunteers and the patients after therapy. The elevated nitrite-nitrate serum levels in the inflammatory period may suggest the possible role of this mediator in the etiopathogenesis of psoriasis and the potential future use of NO inhibitors in the treatment of psoriasis.