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Mediators of Inflammation
Volume 2006, Article ID 16043, 5 pages
http://dx.doi.org/10.1155/MI/2006/16043
Research Communication

Nitric Oxide Levels in Patients with Psoriasis Treated with Methotrexate

1Department of Dermatology, Medical Faculty, Zonguldak Karaelmas University, Zonguldak 67600, Turkey
2Department of Dermatology, Medical Faculty, Gazi University, Ankara 06100, Turkey
3Department of Biochemistry, Medical Faculty, Gazi University, Ankara 06100, Turkey
4Department of Dermatology, Medical Faculty, Yeditepe University, Istanbul 34100, Turkey

Received 13 February 2006; Revised 14 March 2006; Accepted 16 March 2006

Copyright © 2006 Nilgun Solak Tekin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D Bruch-Gerharz, T Ruzicka, and V Kolb-Bachofen, “Nitric oxide in human skin: current status and future prospects,” The Journal of Investigative Dermatology, vol. 110, no. 1, pp. 1–7, 1998. View at Publisher · View at Google Scholar · View at PubMed
  2. J F Schlaak, M Buslau, W Jochum et al., “T cells involved in psoriasis vulgaris belong to the Th1 subset,” The Journal of Investigative Dermatology, vol. 102, no. 2, pp. 145–149, 1994. View at Publisher · View at Google Scholar
  3. J D Bos, Skin Immune System, CRC Press, Boca Raton, Fla, 2nd edition, 1997.
  4. J D Bos and M A De Rie, “The pathogenesis of psoriasis: immunological facts and speculations,” Immunology Today, vol. 20, no. 1, pp. 40–46, 1999. View at Publisher · View at Google Scholar · View at PubMed
  5. N Ortonne and J P Ortonne, “Psoriasis. Patogénie,” La Presse Médicale, vol. 28, no. 23, pp. 1259–1265, 1999. View at Google Scholar · View at PubMed
  6. M G Davies, G J Fulton, and P O Hagen, “Clinical biology of nitric oxide,” The British Journal of Surgery, vol. 82, no. 12, pp. 1598–1610, 1995. View at Google Scholar · View at PubMed
  7. R M Clancy, A R Amin, and S B Abramson, “The role of nitric oxide in inflammation and immunity,” Arthritis and Rheumatism, vol. 41, no. 7, pp. 1141–1151, 1998. View at Publisher · View at Google Scholar · View at PubMed
  8. R Weller and A Ormerod, “Increased expression of inducible nitric oxide (NO) synthase,” The British Journal of Dermatology, vol. 136, no. 1, pp. 136–137, 1997. View at Google Scholar · View at PubMed
  9. D Bruch-Gerharz, K Fehsel, C Suschek, G Michel, T Ruzicka, and V Kolb-Bachofen, “A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes,” The Journal of Experimental Medicine, vol. 184, no. 5, pp. 2007–2012, 1996. View at Publisher · View at Google Scholar · View at PubMed
  10. N R Gokhale, V A Belgaumkar, D P Pandit, S Deshpande, and D K Damle, “A study of serum nitric oxide levels in psoriasis,” Indian Journal of Dermatology, Venereology and Leprology, vol. 71, no. 3, pp. 175–178, 2005. View at Google Scholar · View at PubMed
  11. V Kolb-Bachofen, K Fehsel, G Michel, and T Ruzicka, “Epidermal keratinocyte expression of inducible nitric oxide synthase in skin lesions of psoriasis vulgaris,” Lancet, vol. 344, no. 8915, p. 139, 1994. View at Publisher · View at Google Scholar · View at PubMed
  12. A Orem, R Aliyazicioglu, E Kiran, B Vanizor, G Cimnocodeit, and O Deger, “The relationship between nitric oxide production and activity of the disease in patients with psoriasis,” Archives of Dermatology, vol. 133, no. 12, pp. 1606–1607, 1997. View at Publisher · View at Google Scholar · View at PubMed
  13. A D Ormerod, R Weller, P {Copeland} et al., “Detection of nitric oxide and nitric oxide synthases in psoriasis,” Archives of Dermatological Research, vol. 290, no. 1-2, pp. 3–8, 1998. View at Publisher · View at Google Scholar · View at PubMed
  14. A Sirsjo, M Karlsson, A Gidlof, O Rollman, and H Torma, “Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytes,” The British Journal of Dermatology, vol. 134, no. 4, pp. 643–648, 1996. View at Google Scholar · View at PubMed
  15. M Heenen, M Laporte, J C Noel, and C de Graef, “Methotrexate induces apoptotic cell death in human keratinocytes,” Archives of Dermatological Research, vol. 290, no. 5, pp. 240–245, 1998. View at Publisher · View at Google Scholar · View at PubMed
  16. V M Heydendael, P I Spuls, B C Opmeer et al., “Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis,” The New England Journal of Medicine, vol. 349, no. 7, pp. 658–665, 2003. View at Publisher · View at Google Scholar · View at PubMed
  17. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, and S R Tannenbaum, “Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids,” Analytical Biochemistry, vol. 126, no. 1, pp. 131–138, 1982. View at Publisher · View at Google Scholar · View at PubMed
  18. P N Bories and C Bories, “Nitrate determination in biological fluids by an enzymatic one-step assay with nitrate reductase,” Clinical Chemistry, vol. 41, no. 6 pt 1, pp. 904–907, 1995. View at Google Scholar · View at PubMed
  19. V Krischel, D Bruch-Gerharz, C Suschek, K D Kroncke, T Ruzicka, and V Kolb-Bachofen, “Biphasic effect of exogenous nitric oxide on proliferation and differentiation in skin derived keratinocytes but not fibroblasts,” The Journal of Investigative Dermatology, vol. 111, no. 2, pp. 286–291, 1998. View at Publisher · View at Google Scholar · View at PubMed
  20. S B Corradin, N Fasel, Y Buchmuller-Rouiller, A Ransijn, J Smith, and J Mauel, “Induction of macrophage nitric oxide production by IFNγ and TNFα is enhanced by IL-10,” European Journal of Immunology, vol. 23, no. 8, pp. 2045–2048, 1993. View at Google Scholar · View at PubMed
  21. E Anggard, “Nitric oxide: mediator, murderer, and medicine,” Lancet, vol. 343, no. 8907, pp. 1199–1206, 1994. View at Publisher · View at Google Scholar · View at PubMed
  22. C J Lowenstein, J L Dinerman, and S H Snyder, “Nitric oxide: a physiologic messenger,” Annals of Internal Medicine, vol. 120, no. 3, pp. 227–237, 1994. View at Google Scholar · View at PubMed
  23. G Gilkeson, C Cannon, J Oates, C Reilly, D Goldman, and M Petri, “Correlation of serum measures of nitric oxide production with lupus disease activity,” Journal of Rheumatology, vol. 26, no. 2, pp. 318–324, 1999. View at Google Scholar
  24. A Rowe, A M Farrel, and C B Bunker, “Constitutive endothelial and inducible nitric oxide synthase in inflammatory dermatoses,” The British Journal of Dermatology, vol. 136, no. 1, pp. 18–23, 1997. View at Publisher · View at Google Scholar
  25. S Sahin, M Önder, B Sancak, N Bukan, and M A Gürer, “The role of nitric oxide in allergic contact dermatitis,” Archives of Dermatological Research, vol. 293, no. 4, pp. 214–217, 2001. View at Publisher · View at Google Scholar
  26. S Taniuchi, T Kojima, K Hara Mt et al., “Increased serum nitrate levels in infants with atopic dermatitis,” Allergy, vol. 56, no. 7, pp. 693–695, 2001. View at Publisher · View at Google Scholar
  27. M R Namazi, “A complementary note on the Morhenn's hypothesis on the pathomechanism of psoriasis,” Immunology Letters, vol. 85, no. 3, p. 223, 2003. View at Publisher · View at Google Scholar
  28. M M Cals-Grierson and A D Ormerod, “Nitric oxide function in the skin,” Nitric Oxide, vol. 10, no. 4, pp. 179–193, 2004. View at Publisher · View at Google Scholar · View at PubMed
  29. P C Kuo and R A Schroeder, “The emerging multifaceted roles of nitric oxide,” Annals of Surgery, vol. 221, no. 3, pp. 220–235, 1995. View at Publisher · View at Google Scholar
  30. G D Weinstein, E Jeffes, and J L McCullough, “Cytotoxic and immunologic effects of methotrexate in psoriasis,” Journal of Investigative Dermatology, vol. 95, no. 5, pp. 49S–52S, 1990. View at Publisher · View at Google Scholar
  31. L Genestier, R Paillot, L Quemeneur, K Izeradjene, and J P Revillard, “Mechanisms of action of methotrexate,” Immunopharmacology, vol. 47, no. 2-3, pp. 247–257, 2000. View at Publisher · View at Google Scholar · View at PubMed
  32. S B Corradin, N Fasel, Y Buchmüller-Roniller, A Ransisjn, J Smith, and J Manuel, “Induction of macrophage nitric oxide production by IFNγ and TNFα is enhanced by IL-10,” European Journal of Immunology, vol. 23, no. 8, pp. 2045–2048, 1993. View at Google Scholar
  33. E A Olsen, “The pharmacology of methotrexate,” Journal of the American Academy of Dermatology, vol. 25, no. 2 pt 1, pp. 306–318, 1991. View at Google Scholar · View at PubMed
  34. T Omata, Y Segawa, N Inoue, N Tsuzuike, Y Itokazu, and H Tamaki, “Methotrexate suppresses nitric oxide production ex vivo in macrophages from rats with adjuvant-induced arthritis,” Research in Experimental Medicine, vol. 197, no. 2, pp. 81–90, 1997. View at Publisher · View at Google Scholar
  35. R A Robbins, P A Jinkins, T W Bryan, S C Prado, and S A Milligan, “Methotrexate inhibition of inducible nitric oxide synthase in murine lung epithelial cells in vitro,” American Journal of Respiratory Cell and Molecular Biology, vol. 18, no. 6, pp. 853–859, 1998. View at Google Scholar
  36. P Durez, T Appelboom, B. Vray, C Pıra, and M Goldman, “Methotrexate inhibits LPS-induced tumor necrosis factor production in vivo,” European Cytokine Network, vol. 9, no. 4, pp. 669–672, 1998. View at Google Scholar