Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients

Coban, Y. Kenan; Aral, Murat

doi:https://doi.org/10.1155/MI/2006/16492

Mediators of Inflammation

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Volume 2006 | Article ID 016492 | https://doi.org/10.1155/MI/2006/16492

Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients

Y. Kenan Coban¹and Murat Aral²

Received24 Jun 2005

Accepted15 Nov 2005

Published12 Mar 2006

Abstract

A severe systemic inflammatory response is usually seen after burn injury. IL-18 enhances the Th1 immune responses in bacterial andviral infections. In order to evaluate the IL-18 serum levels as well as IL-6 and TNF-α at the 48th hour postburn, serial serum samples of 8 burned patients were analyzed. 8 moderately burned patients were included into the study. Serum samples were taken at admission at the 48th hour of postburn. IL-6, IL-18, and TNF-α serum levels were analyzed. Total mean burned surface area (TBSA) was 24.6±5.7% and mean BMI (body mass index) was 24.5±3.4. The patients' age ranged from 17 to 38 (mean 26.3±7.4) years. An increase in sera IL-6, IL-18, and TNF-α was detected at the 48th hour postburn (P<.0001). All patients survived. A marked increase in serum levels of IL-18 as well as the other cytokines evaluated was observed in the moderately burned patients. These three parameters were highly correlated with each other (r>0.9 and P<.001). This is the first study that shows an increase in serum IL-18 levels at the early postburn period.

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Copyright

Copyright © 2006 Y. Kenan Coban and Murat Aral. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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