Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2006, Article ID 18061, 5 pages
http://dx.doi.org/10.1155/MI/2006/18061
Short Communication

Detection of Erythropoietin in Exhaled Breath Condensate of Nonhypoxic Subjects Using a Multiplex Bead Array

1Department of Internal Medicine II, Section of Pulmonary Medicine, University of Ulm, Robert-Koch-Straβe 8 89081, Ulm, Germany
2Infection and Immunity Group, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK
3Research Society of Lung and Chest Diseases Ltd, Berlin 13125, Germany
4Department of Intensive Care Medicine, Inselspital, University of Bern, Bern 3010, Switzerland

Received 27 April 2006; Revised 23 August 2006; Accepted 23 August 2006

Copyright © 2006 Christian Schumann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G E Carpagnano, S A Kharitonov, O Resta, M P Foschino-Barbaro, E Gramiccioni, and P J Barnes, “8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy,” Chest, vol. 124, no. 4, pp. 1386–1392, 2003. View at Publisher · View at Google Scholar
  2. P Montuschi, S A Kharitonov, G Ciabattoni, and P J Barnes, “Exhaled leukotrienes and prostaglandins in COPD,” Thorax, vol. 58, no. 7, pp. 585–588, 2003. View at Publisher · View at Google Scholar
  3. C Mondino, G Ciabattoni, P Koch et al., “Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children,” Journal of Allergy and Clinical Immunology, vol. 114, no. 4, pp. 761–767, 2004. View at Publisher · View at Google Scholar · View at PubMed
  4. U Sack, R Scheibe, M Wōtzel et al., “Multiplex analysis of cytokines in exhaled breath condensate,” Cytometry Part A, vol. 69, no. 3, pp. 169–172, 2006. View at Publisher · View at Google Scholar · View at PubMed
  5. L Scheideler, H-G Manke, U Schwulera, O Inacker, and H Hammerle, “Detection of nonvolatile macromolecules in breath: a possible diagnostic tool?,” American Review of Respiratory Disease, vol. 148, no. 3, pp. 778–784, 1993. View at Google Scholar
  6. J Hunt, “Exhaled breath condensate: an evolving tool for noninvasive evaluation of lung disease,” Journal of Allergy and Clinical Immunology, vol. 110, no. 1, pp. 28–34, 2002. View at Publisher · View at Google Scholar
  7. Z Z Chong, J-Q Kang, and K Maiese, “Angiogenesis and plasticity: role of erythropoietin in vascular systems,” Journal of Hematotherapy and Stem Cell Research, vol. 11, no. 6, pp. 863–871, 2002. View at Publisher · View at Google Scholar · View at PubMed
  8. Z Z Chong, J-Q Kang, and K Maiese, “Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades,” Journal of Cerebral Blood Flow and Metabolism, vol. 22, no. 5, pp. 503–514, 2002. View at Google Scholar
  9. S Genc, T F Koroglu, and K Genc, “Erythropoietin as a novel neuroprotectant,” Restorative Neurology and Neuroscience, vol. 22, no. 2, pp. 105–119, 2004. View at Google Scholar
  10. K Maiese and Z Z Chong, “Insights into oxidative stress and potential novel therapeutic targets for Alzheimer disease,” Restorative Neurology and Neuroscience, vol. 22, no. 2, pp. 87–104, 2004. View at Google Scholar
  11. K Sakamaki, “Regulation of endothelial cell death and its role in angiogenesis and vascular regression,” Current Neurovascular Research, vol. 1, no. 4, pp. 305–315, 2004. View at Publisher · View at Google Scholar
  12. K Satoh, Y Kagaya, M Nakano et al., “Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice,” Circulation, vol. 113, no. 11, pp. 1442–1450, 2006. View at Publisher · View at Google Scholar · View at PubMed
  13. A E Tsantes, S I Papadhimitriou, S T Tassiopoulos et al., “Red cell macrocytosis in hypoxemic patients with chronic obstructive pulmonary disease,” Respiratory Medicine, vol. 98, no. 11, pp. 1117–1123, 2004. View at Publisher · View at Google Scholar
  14. M John, S Hoernig, W Doehner, D D Okonko, C Witt, and S D Anker, “Anemia and inflammation in COPD,” Chest, vol. 127, no. 3, pp. 825–829, 2005. View at Publisher · View at Google Scholar · View at PubMed
  15. M John, A Lange, S Hoernig, C Witt, and S D Anker, “Prevalence of anemia in chronic obstructive pulmonary disease: comparison to other chronic diseases,” International Journal of Cardiology, vol. 111, no. 3, pp. 365–370, 2006. View at Publisher · View at Google Scholar · View at PubMed
  16. I Horváth, J Hunt, P J Barnes et al., “Exhaled breath condensate: methodological recommendations and unresolved questions,” European Respiratory Journal, vol. 26, no. 3, pp. 523–548, 2005. View at Publisher · View at Google Scholar · View at PubMed
  17. P H Quanjer, G J Tammeling, J E Cotes, O F Pedersen, R Peslin, and J C Yernault, “Lung volumes and forced ventilatory flows. Report working party standardization of lung function tests, European community for steel and coal. Official statement of the European respiratory society,” The European Respiratory Journal. Supplement, vol. 16, pp. 5–40, 1993. View at Google Scholar
  18. C Gessner, S Hammerschmidt, H Kuhn et al., “Exhaled breath condensate acidification in acute lung injury,” Respiratory Medicine, vol. 97, no. 11, pp. 1188–1194, 2003. View at Publisher · View at Google Scholar
  19. C Gessner, S Hammerschmidt, H Kuhn, and H Wirtz, “Expired diagnosis?—The potential of exhaled breath analysis,” Pneumologie, vol. 58, no. 4, pp. 230–237, 2004. View at Publisher · View at Google Scholar · View at PubMed
  20. C Gessner, H Kuhn, K Toepfer, S Hammerschmidt, J Schauer, and H Wirtz, “Detection of p53 gene mutations in exhaled breath condensate of non-small cell lung cancer patients,” Lung Cancer, vol. 43, no. 2, pp. 215–222, 2004. View at Publisher · View at Google Scholar
  21. C Gessner, R Scheibe, M Wōtzel et al., “Exhaled breath condensate cytokine patterns in chronic obstructive pulmonary disease,” Respiratory Medicine, vol. 99, no. 10, pp. 1229–1240, 2005. View at Publisher · View at Google Scholar · View at PubMed
  22. K W Garey, M M Neuhauser, R A Robbins, L H Danziger, and I Rubinstein, “Markers of inflammation in exhaled breath condensate of young healthy smokers,” Chest, vol. 125, no. 1, pp. 22–26, 2004. View at Publisher · View at Google Scholar
  23. D Kietzmann, R Kahl, M Muller, H Burchardi, and D Kettler, “Hydrogen peroxide in expired breath condensate of patients with acute respiratory failure and with ARDS,” Intensive Care Medicine, vol. 19, no. 2, pp. 78–81, 1993. View at Publisher · View at Google Scholar
  24. R M Effros, K W Hoagland, M Bosbous et al., “Dilution of respiratory solutes in exhaled condensates,” American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 5, pp. 663–669, 2002. View at Google Scholar
  25. R M Effros, J Biller, B Foss et al., “A simple method for estimating respiratory solute dilution in exhaled breath condensates,” American Journal of Respiratory and Critical Care Medicine, vol. 168, no. 12, pp. 1500–1505, 2003. View at Publisher · View at Google Scholar · View at PubMed
  26. T M Dwyer, “Cigarette smoke-induced airway inflammation as sampled by the expired breath condensate,” American Journal of the Medical Sciences, vol. 326, no. 4, pp. 174–178, 2003. View at Publisher · View at Google Scholar
  27. A Zacharasiewicz, N Wilson, C Lex et al., “Repeatability of sodium and chloride in exhaled breath condensates,” Pediatric Pulmonology, vol. 37, no. 3, pp. 273–275, 2004. View at Publisher · View at Google Scholar · View at PubMed
  28. W Y Park, R B Goodman, K P Steinberg et al., “Cytokine balance in the lungs of patients with acute respiratory distress syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 10 pt I, pp. 1896–1903, 2001. View at Google Scholar
  29. C J Parsa, J Kim, R U Riel et al., “Cardioprotective effects of erythropoietin in the reperfused ischemic heart: a potential role for cardiac fibroblasts,” Journal of Biological Chemistry, vol. 279, no. 20, pp. 20655–20662, 2004. View at Publisher · View at Google Scholar · View at PubMed
  30. R M Effros, M B III Dunning, J Biller, and R Shaker, “The promise and perils of exhaled breath condensates,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 287, no. 6, pp. L1073–L1080, 2004. View at Publisher · View at Google Scholar · View at PubMed
  31. E Gianazza, L Allegra, E Bucchioni et al., “Increased keratin content detected by proteomic analysis of exhaled breath condensate from healthy persons who smoke,” American Journal of Medicine, vol. 117, no. 1, pp. 51–54, 2004. View at Publisher · View at Google Scholar · View at PubMed
  32. A R Nissenson, S D Nimer, and D L Wolcott, “Recombinant human erythropoietin and renal anemia: molecular biology, clinical efficacy, and nervous system effects,” Annals of Internal Medicine, vol. 114, no. 5, pp. 402–416, 1991. View at Google Scholar