Is the Association Between TNF-<mml:math id="E1" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>α</mml:mi></mml:math>-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?

Deja, Grazyna; Jarosz-Chobot, Przemyslawa; Polanska, Joanna; Siekiera, Urszula; Malecka-Tendera, Ewa

doi:https://doi.org/10.1155/MI/2006/19724

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 019724 | https://doi.org/10.1155/MI/2006/19724

Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?

Grazyna Deja,¹Przemyslawa Jarosz-Chobot,¹Joanna Polanska,²Urszula Siekiera,³and Ewa Malecka-Tendera¹

Received12 Jan 2006

Revised25 Mar 2006

Accepted05 Apr 2006

Published06 Jul 2006

Abstract

The aim of the study was to assess chosen factors of genetic susceptibility to DMT1: DRB1, DQB1, and TNF-α polymorphisms-308 (G/A) in children with DMT1 and their up-to-now healthy siblings. Then we tested whether the association between TNF-α genes and DMT1 is independent of HLA. 87 diabetic children, their 78 siblings, and 85 persons from healthy control group were followed up. The highest risk of DMT1 was connected with alleles: DRB1*0401 (OR = 3.39; CI: 1.55–7.41), DRB1*0301 (OR = 2.72; CI: 1.48–5.01), DQB1*0201 (OR = 4.04; CI: 2.17–7.52), DQB1*0302 (OR = 5.08; CI: 2.54–10.14), and TNF-α-308 A allele (OR = 2.59; CI: 1.23–5.44). Moreover linkage disequilibrium for TNF-α-308 A allele with DRB1*0301 and DQB1*0201 was observed in both diabetic children and their siblings. Diabetic children and their siblings present similar genetic risk factors for DMT1. The association between TNF-α-308 A allele and DMT1 is dependent of HLA-DRB1 and DQB1 alleles.

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Copyright © 2006 Grażyna Deja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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