Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein

Kishimoto, Kazuya; Kaneko, Satoshi; Ohmori, Kenji; Tamura, Tadafumi; Hasegawa, Kazuhide

doi:https://doi.org/10.1155/MI/2006/42726

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 042726 | https://doi.org/10.1155/MI/2006/42726

Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein

Kazuya Kishimoto,¹Satoshi Kaneko,¹Kenji Ohmori,¹Tadafumi Tamura,¹and Kazuhide Hasegawa¹

Received13 Sept 2005

Accepted13 Oct 2005

Published05 Feb 2006

Abstract

Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H1 receptor antagonistic activity. Recently, olopatadine has been shown to bind to S100A12 which is a member of the S100 family of calcium-binding proteins, and exerts multiple proinflammatory activities including chemotaxis for monocytes and neutrophils. In this study, we examined the possibility that the interaction of olopatadine with S100A12 inhibits the proinflammatory effects of S100A12. Pretreatment of olopatadine with S100A12 reduced migration of THP-1, a monocyte cell line, induced by S100A12 alone, but did not affect recombinant human regulated upon activation, normal T cell expressed and secreted (RANTES)-induced migration. Amlexanox, which also binds to S100A12, inhibited the THP-1 migration induced by S100A12. However, ketotifen, another histamine H1 receptor antagonist, had little effect on the activity of S100A12. These results suggest that olopatadine has a new mechanism of action, that is, suppression of the function of S100A12, in addition to histamine H1 receptor antagonistic activity.

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Copyright

Copyright © 2006 Kazuya Kishimoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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