The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates

Okino, Alessandra M.; Bürger, Cristiani; Cardoso, Jefferson R.; Lavado, Edson L.; A. Lotufo, Paulo; Campa, Ana

doi:https://doi.org/10.1155/MI/2006/47297

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 047297 | https://doi.org/10.1155/MI/2006/47297

The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates

Alessandra M. Okino,^1,2Cristiani Bürger,^2,3Jefferson R. Cardoso,⁴Edson L. Lavado,⁴Paulo A. Lotufo,⁵and Ana Campa²

Received24 Aug 2005

Accepted06 Oct 2005

Published08 Feb 2006

Abstract

The distinction between exudates and transudates is very important in the patient management. Here we evaluate whether the acute-phase protein serum amyloid A (SAA), in comparison with C reactive protein (CRP) and total protein (TP), can be useful in this discrimination. CRP, SAA, and TP were determined in 36 exudate samples (27 pleural and 9 ascitic) and in 12 transudates (9 pleural and 3 ascitic). CRP, SAA, and TP were measured. SAA present in the exudate corresponded to 10% of the amount found in serum, that is, the exudate/serum ratio (E/S) was 0.10±0.13. For comparison, the exudate/serum ratio for CRP and TP was 0.39±0.37 and 0.68±0.15, respectively. There was a strong positive correlation between serum and exudate SAA concentration (r=0.764;p<0.0001). The concentration of SAA in transudates was low and did not overlap with that found in exudates (0.02-0.21 versus 0.8–360.5 g/mL). SAA in pleural and ascitic exudates results mainly from leakage of the serum protein via the inflamed membrane. A comparison of the E/S ratio of SAA and CRP points SAA as a very good marker in discriminating between exudates and transudates

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Copyright © 2006 Alessandra M. Okino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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