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Mediators of Inflammation
Volume 2006, Article ID 54202, 8 pages
http://dx.doi.org/10.1155/MI/2006/54202
Research Communication

Systemic and Local CC Chemokines Production in a Murine Model of Listeria monocytogenes Infection

1Department of Microbiology, Medical Faculty, University of Rijeka, Rijeka 51000, Croatia
2Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Ljubljana 1000, Slovenia
3Department of Medical Informatics, Medical Faculty, University of Rijeka, Rijeka 51000, Croatia

Received 29 December 2005; Revised 17 February 2006; Accepted 19 February 2006

Copyright © 2006 Marina Bubonja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Repeated intragastric inoculation of Listeria monocytogenes into BALB/c mice resulted in prolonged bacteraemia and severe hepatic infection. Bacteria could also be isolated from the brain tissue of all experimental mice. During the inflammatory process, chemokine concentrations typically increased at the local site in comparison to the systemic level. The liver-to-serum ratio was more pronounced in the case of macrophage inflammatory protein 1α (MIP-1α), suggesting its role in the inflammatory response in the liver. The ratio of brain-to-serum concentration of monocyte chemoattractant protein 1 (MCP-1) remained the same as in the control animals, while it was lower in the infected mice, both in the case MIP-1α and in the case of regulated on activation, normal T cell expressed and secreted (RANTES). This is in correlation with slight inflammatory infiltrates found in the brain tissue early in infection.