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Mediators of Inflammation
Volume 2006, Article ID 54632, 4 pages
Short Communication

Detection of Salivary Interleukin 2 and Interleukin 6 in Patients With Burning Mouth Syndrome

School of Dentistry, Medical Faculty, University of Rijeka, Rijeka 51000, Croatia

Received 13 September 2005; Accepted 3 November 2005

Copyright © 2006 Daria Simčić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers (control group). Whole saliva from 30 patients with BMS, age range 55–65, was tested for the presence of IL-6 and IL-2 by enzyme immunoassay. Control group consisted of 30 healthy participants, aged 55–65 years. Saliva IL-2 concentrations in BMS were significantly increased in patients compared to healthy subjects: mean 34.1±9.7 versus 7.3±3.0 pg/mL; P<.001. Patients with BMS had significantly higher concentrations of IL-6 compared to control: mean 30.8±5.6 versus 5.2±2.8 pg/mL; P<.001. In patients with BMS, IL-2 and IL-6 levels in saliva are elevated, correlating with the severity of illness.