Detection of Salivary Interleukin 2 and Interleukin 6 in Patients With Burning Mouth Syndrome

Simcic, Daria; Pezelj-Ribaric, Sonja; Gržic, Renata; Horvat, Jelena; Brumini, Gordana; Muhvic-Urek, Miranda

doi:https://doi.org/10.1155/MI/2006/54632

Mediators of Inflammation

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Volume 2006 | Article ID 054632 | https://doi.org/10.1155/MI/2006/54632

Detection of Salivary Interleukin 2 and Interleukin 6 in Patients With Burning Mouth Syndrome

Daria Simcic,¹Sonja Pezelj-Ribaric,¹Renata Gržic,¹Jelena Horvat,¹Gordana Brumini,¹and Miranda Muhvic-Urek¹

Received13 Sept 2005

Accepted03 Nov 2005

Published06 Feb 2006

Abstract

The etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers (control group). Whole saliva from 30 patients with BMS, age range 55–65, was tested for the presence of IL-6 and IL-2 by enzyme immunoassay. Control group consisted of 30 healthy participants, aged 55–65 years. Saliva IL-2 concentrations in BMS were significantly increased in patients compared to healthy subjects: mean 34.1±9.7 versus 7.3±3.0 pg/mL; P<.001. Patients with BMS had significantly higher concentrations of IL-6 compared to control: mean 30.8±5.6 versus 5.2±2.8 pg/mL; P<.001. In patients with BMS, IL-2 and IL-6 levels in saliva are elevated, correlating with the severity of illness.

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Copyright © 2006 Daria Simčić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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