Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2006 (2006), Article ID 59206, 6 pages
http://dx.doi.org/10.1155/MI/2006/59206
Research Communication

Serum IL-1β, IL-2, and IL-6 in Insulin-Dependent Diabetic Children

1Department of Pediatrics, Medical Faculty, Firat University, Elazig 23119, Turkey
2Department of Biochemistry, Medical Faculty, Firat University, Elazig 23119, Turkey

Received 10 July 2005; Accepted 28 October 2005

Copyright © 2006 Yasar Dogan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A Kukreja, G Cost, J Marker et al., “Multiple immuno-regulatory defects in type-1 diabetes,” The Journal of Clinical Investigation, vol. 109, no. 1, pp. 131–140, 2002. View at Publisher · View at Google Scholar · View at PubMed
  2. M G Karlsson Faresjo, J Ernerudh, and J Ludvigsson, “Cytokine profile in children during the first 3 months after the diagnosis of type 1 diabetes,” Scandinavian Journal of Immunology, vol. 59, no. 5, pp. 517–526, 2004. View at Publisher · View at Google Scholar · View at PubMed
  3. M J Hussain, J Maher, T Warnock, A Vats, M Peakman, and D Vergani, “Cytokine overproduction in healthy first degree relatives of patients with IDDM,” Diabetologia, vol. 41, no. 3, pp. 343–349, 1998. View at Publisher · View at Google Scholar · View at PubMed
  4. A B Erbagci, M Tarakcioglu, Y Coskun, E Sivasli, and E Sibel Namiduru, “Mediators of inflammation in children with type I diabetes mellitus: cytokines in type I diabetic children,” Clinical Biochemistry, vol. 34, no. 8, pp. 645–650, 2001. View at Publisher · View at Google Scholar · View at PubMed
  5. D L Eizirik, S Sandler, N Welsh et al., “Cytokines suppress human islet function irrespective of their effects on nitric oxide generation,” The Journal of Clinical Investigation, vol. 93, no. 5, pp. 1968–1974, 1994. View at Google Scholar · View at PubMed
  6. H Tchorzewski, E Glowacka, M Banasik, P Lewkowicz, and M Szalapska-Zawodniak, “Activated T lymphocytes from patients with high risk of type I diabetes mellitus have different ability to produce interferon-gamma, interleukin-6 and interleukin-10 and undergo anti-CD95 induced apoptosis after insulin stimulation,” Immunology Letters, vol. 75, no. 3, pp. 225–234, 2001. View at Publisher · View at Google Scholar · View at PubMed
  7. M J Rapoport, A Mor, P Vardi et al., “Decreased secretion of Th2 cytokines precedes Up-regulated and delayed secretion of Th1 cytokines in activated peripheral blood mononuclear cells from patients with insulin-dependent diabetes mellitus,” Journal of Autoimmunity, vol. 11, no. 6, pp. 635–642, 1998. View at Publisher · View at Google Scholar · View at PubMed
  8. A El-Nawawy, T Soliman, O El-Azzouni et al., “Interleukin-1-beta, tumor necrosis factor-alpha, insulin secretion and oral glucose tolerance in non-diabetic siblings of children with IDDM,” Indian Journal of Pediatrics, vol. 65, no. 3, pp. 455–460, 1998. View at Google Scholar · View at PubMed
  9. M G Netea, N Hancu, W L Blok et al., “Interleukin 1 beta, tumour necrosis factor-alpha and interleukin 1 receptor antagonist in newly diagnosed insulin-dependent diabetes mellitus: comparison to long-standing diabetes and healthy individuals,” Cytokine, vol. 9, no. 4, pp. 284–287, 1997. View at Publisher · View at Google Scholar · View at PubMed
  10. G Ozer, Z Teker, S Cetiner et al., “Serum IL-1, IL-2, TNF-alpha and INF-gamma levels of patients with type 1 diabetes mellitus and their siblings,” Journal of Pediatric Endocrinology & Metabolism, vol. 16, no. 2, pp. 203–210, 2003. View at Google Scholar · View at PubMed
  11. A Rabinovitch and W L Suarez-Pinzon, “Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus,” Biochemical Pharmacology, vol. 55, no. 8, pp. 1139–1149, 1998. View at Publisher · View at Google Scholar · View at PubMed
  12. G Davi, F Chiarelli, F Santilli et al., “Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration,” Circulation, vol. 107, no. 25, pp. 3199–3203, 2003. View at Publisher · View at Google Scholar · View at PubMed
  13. G Targher, L Zenari, L Bertolini, M Muggeo, and G Zoppini, “Elevated levels of interleukin-6 in young adults with type 1 diabetes without clinical evidence of microvascular and macrovascular complications,” Diabetes Care, vol. 24, no. 5, pp. 956–957, 2001. View at Google Scholar · View at PubMed
  14. B Kulseng, G Skjak-Braek, I Folling, and T Espevik, “TNF production from peripheral blood mononuclear cells in diabetic patients after stimulation with alginate and lipopolysaccharide,” Scandinavian Journal of Immunology, vol. 43, no. 3, pp. 335–340, 1996. View at Google Scholar · View at PubMed
  15. S E Geerlings, E C Brouwer, K C Van Kessel, W Gaastra, R P Stolk, and A I Hoepelman, “Cytokine secretion is impaired in women with diabetes mellitus,” European Journal of Clinical Investigation, vol. 30, no. 11, pp. 995–1001, 2000. View at Publisher · View at Google Scholar · View at PubMed
  16. J C Pickup, G D Chusney, S M Thomas, and D Burt, “Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes,” Life Sciences, vol. 67, no. 3, pp. 291–300, 2000. View at Publisher · View at Google Scholar · View at PubMed
  17. P Peraldi and B Spiegelman, “TNF-alpha and insulin resistance: summary and future prospects,” Molecular and Cellular Biochemistry, vol. 182, no. 1-2, pp. 169–175, 1998. View at Publisher · View at Google Scholar · View at PubMed
  18. M I Schmidt, B B Duncan, A R Sharrett et al., “Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study,” Lancet, vol. 353, no. 9165, pp. 1649–1652, 1999. View at Publisher · View at Google Scholar · View at PubMed
  19. C C Gerhardt, I A Romero, R Cancello, L Camoin, and A D Strosberg, “Chemokines control fat accumulation and leptin secretion by cultured human adipocytes,” Molecular and Cellular Endocrinology, vol. 175, no. 1-2, pp. 81–92, 2001. View at Publisher · View at Google Scholar · View at PubMed
  20. J L Wautier, C Zoukourian, O Chappey et al., “Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats,” The Journal of Clinical Investigation, vol. 97, no. 1, pp. 238–243, 1996. View at Google Scholar · View at PubMed
  21. A M Schmidt, O Hori, R Cao et al., “RAGE: a novel cellular receptor for advanced glycation end products,” Diabetes, vol. 45, no. suppl 3, pp. S77–S80, 1996. View at Google Scholar · View at PubMed
  22. T Tomoda, T Kurashige, and T Taniguchi, “Imbalance of the interleukin 2 system in children with IDDM,” Diabetologia, vol. 37, no. 5, pp. 476–482, 1994. View at Publisher · View at Google Scholar · View at PubMed
  23. W A Kaye, M N Adri, J S Soeldner et al., “Acquired defect in interleukin-2 production in patients with type I diabetes mellitus,” The New England Journal of Medicine, vol. 315, no. 15, pp. 920–924, 1986. View at Google Scholar · View at PubMed
  24. R Lorini, D Montagna, A Lanfranchi et al., “Alterations of in vitro interleukin 1 and 2 in diabetic children,” European Journal of Pediatrics, vol. 148, no. 8, pp. 732–734, 1989. View at Publisher · View at Google Scholar · View at PubMed
  25. W Huang, D S Wang, X Y Li, W Z Wu, and G C Ni, “Expression levels of IL-6 mRNA in PBMNCs from patients with IDDM, NIDDM and normals by RT-PCR procedure,” Chinese Medical Journal, vol. 106, no. 12, pp. 893–897, 1993. View at Google Scholar · View at PubMed
  26. U Shah, L Karch, L Baker, and K S Zier, “Low interleukin-2 synthesis by type 1 diabetics is regulated at the pretranslational level,” Clinical Immunology and Immunopathology, vol. 61, no. 2 pt 1, pp. 177–190, 1991. View at Publisher · View at Google Scholar · View at PubMed
  27. M G Roncarolo, M Zoppo, R Bacchetta et al., “Interleukin-2 production and interleukin-2 receptor expression in children with newly diagnosed diabetes,” Clinical Immunology and Immunopathology, vol. 49, no. 1, pp. 53–62, 1988. View at Publisher · View at Google Scholar · View at PubMed
  28. A Kretowski, J Mysliwiec, M Szelachowska, C Brzozowski, M Pietruczuk, and I Kinalska, “In vitro secretion of interleukin 2 and expression of IL-2 receptor in peripheral blood lymphocytes in high risk of insulin-dependent diabetes mellitus subjects,” Archivum Immunologiae et Therapiae Experimentalis, vol. 47, no. 1, pp. 45–49, 1999. View at Google Scholar · View at PubMed
  29. R Wagner, E Bonifacio, P J Bingley, S Genovese, D Reinwein, and G F Bottazzo, “Low interleukin-2 receptor levels in serum of patients with insulin-dependent diabetes,” The Clinical Investigator, vol. 72, no. 7, pp. 494–498, 1994. View at Google Scholar · View at PubMed
  30. L A Gartner, M C Pfeifer, C Albini, and G L Francis, “Soluble interleukin 2 receptor levels in children with type I insulin-dependent diabetes mellitus,” Annals of Clinical and Laboratory Science, vol. 25, no. 1, pp. 44–51, 1995. View at Google Scholar · View at PubMed
  31. K S Zier, M M Leo, R S Spielman, and L Baker, “Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus,” Diabetes, vol. 33, no. 6, pp. 552–555, 1984. View at Google Scholar · View at PubMed
  32. A Wedrychowicz, H Dziatkowiak, K Sztefko, and A Wedrychowicz, “Interleukin-6 (IL-6) and IGF-IGFBP system in children and adolescents with type 1 diabetes mellitus,” Experimental and Clinical Endocrinology & Diabetes, vol. 112, no. 8, pp. 435–439, 2004. View at Google Scholar · View at PubMed
  33. S K Jain, K Kannan, G Lim, J Matthews-Greer, R McVie, and J A Jr Bocchini, “Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes,” Diabetes Care, vol. 26, no. 7, pp. 2139–2143, 2003. View at Google Scholar · View at PubMed