Tumor Necrosis Factor-<mml:math id="E1" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>α</mml:mi></mml:math> in Temporomandibular Joint Synovial Fluid Predicts Treatment Effects on Pain by Intra-Articular Glucocorticoid Treatment

Fredriksson, Lars; Alstergren, Per; Kopp, Sigvard

doi:https://doi.org/10.1155/MI/2006/59425

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 059425 | https://doi.org/10.1155/MI/2006/59425

Tumor Necrosis Factor-α in Temporomandibular Joint Synovial Fluid Predicts Treatment Effects on Pain by Intra-Articular Glucocorticoid Treatment

Lars Fredriksson,¹Per Alstergren,¹and Sigvard Kopp¹

Received21 Aug 2006

Revised15 Sept 2006

Accepted18 Sept 2006

Published16 Nov 2006

Abstract

The aim of this study was to investigate the influence of tumor necrosis factor-α (TNF-α) in temporomandibular joint (TMJ) synovial fluid and blood on the treatment effect on TMJ pain by intra-articular injection of glucocorticoid in patients with chronic inflammatory TMJ disorders. High pretreatment level of TNF-α in the synovial fluid was associated with a decrease of TNF-α and elimination of pain upon maximal mouth opening. Elimination of this TMJ pain was accordingly associated with decrease in synovial fluid level of TNF-α. There was also a significant decrease of C-reactive protein and TMJ resting pain after treatment. In conclusion, this study indicates that presence of TNF-α in the synovial fluid predicts a treatment effect of intra-articular injection of glucocorticoid on TMJ movement pain in patients with chronic TMJ inflammatory disorders.

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Copyright

Copyright © 2006 Lars Fredriksson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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