Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation

Nilkaeo, Athip; Bhuvanath, Suthinee

doi:https://doi.org/10.1155/MI/2006/67120

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 067120 | https://doi.org/10.1155/MI/2006/67120

Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation

Athip Nilkaeo¹and Suthinee Bhuvanath¹

Received22 Jan 2006

Accepted24 Feb 2006

Published23 Mar 2006

Abstract

Interleukin-18 (IL-18), a proinflammatory cytokine, is produced by oral epithelia and carcinoma cells and implicated in tumor regression. Since its direct biological effect on oral cancer cells is not well defined, in this study, we employed a KB cell line to test IL-18 activity. Recombinant human IL-18 significantly inhibited KB cell proliferation in a dose-dependent fashion (P<.05) without increasing cytotoxicity. Analysis of its mode of action showed that IL-18 induced cell cycle arrest in the S phase; however, it did not trigger apoptotic cell death. Findings in this study indicate that the suppression of KB cell proliferation was attributed to the modulation of cell cycle progression, providing a new role of this cytokine in antitumor mechanisms.

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Copyright

Copyright © 2006 Athip Nilkaeo and Suthinee Bhuvanath. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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