Background/Aim. Malnutrition, a common problem in liver
cirrhosis and HCC, may readily deteriorate the clinical functions
with resultant poor prognosis. Beside the hyper catabolic state
frequently encountered in chronic liver disease and HCC, anorexia
and reduced food intake also worsen the malnutrition. The recently
discovered peptide hormone ghrelin acts as a counterpart of leptin
in regulation of food intake and fat utilization. The aim of the
present study was to investigate the ghrelin and leptin levels in
cirrhosis and HCC due to hepatitis B and D viruses, and the
association of ghrelin and leptin with TNF-α, IL-6 and the severity of the disease. Materials and methods. We
measured serum ghrelin, leptin, TNF-α, and IL-6 levels using specific immunoassay in 45 patients (23 cirrhosis, 22 HCC)
with HBV and/or HDV and in 25 control subjects. Results.
In comparison to controls, serum ghrelin, TNF-α, and IL-6 levels were significantly higher in cirrhosis and HCC (P<.05), whereas serum leptin levels were found decreased (P<.05). There was a positive correlation between ghrelin and TNF-α, and a negative correlation between leptin and TNF-α (P<.05). Conclusion. In cirrhosis and HCC due to HBV or HDV, serum
ghrelin levels were increased with a corresponding decrease in
serum leptin concentrations, acting as a physiological counterpart
of ghrelin. The increasing of ghrelin is more prominent in Child
C cirrhosis and the level was correlated with TNF-α. The presence of nutritional and metabolic abnormalities, including
malnutrition, in cirrhosis and HCC may, at least partly, elucidate high ghrelin and low leptin levels.