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Mediators of Inflammation
Volume 2006, Article ID 81767, 6 pages
Research Communication

Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis

1Department of Dermatology and Venereology, Medical University of Łódź, 5 Krzemieniecka Street, Łódź 94-017, Poland
2Department of Clinical Immunology, Polish Mother’s Memorial Hospital-Research Institute, 93-338 Łódź, Poland
3Centre for Medical Biology, Polish Academy of Sciences, Łódź 93-232, Poland

Received 21 September 2005; Accepted 20 October 2005

Copyright © 2006 Anna Zalewska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fibroblasts have been implicated in psoriatic inflammatory processes. The aim of the study was to evaluate soluble interleukin 2 receptor (sIL-2R), interleukin 6 (IL-6), and interleukin 8 (IL-8) plasma levels in psoriatic patients and IL-6 and IL-8 levels in fibroblast culture supernatants. Cytokines levels in plasma and supernatants were measured by ELISA. Plasma sIL-2R, IL-6, and IL-8 levels were higher before the treatment in comparison to healthy controls (P<0.001) and decreased after treatment. Fibroblasts from healthy controls, psoriatic lesional skin, and noninvolved psoriatic skin, when stimulated with tumor necrosis factor alpha, released considerable amounts of IL-6 and IL-8. No significant difference between healthy controls and psoriatic fibroblasts was observed. Monitoring plasma sIL-2R levels could be employed as a reliable method of psoriasis activity. IL-8 and IL-6 plasma levels seem to reflect psoriasis activity, and treatment response, respectively. Fibroblasts are not a major source of increased IL-6 and IL-8 production in psoriasis.