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Mediators of Inflammation
Volume 2006, Article ID 93253, 10 pages
http://dx.doi.org/10.1155/MI/2006/93253
Research Communication

Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis

Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China

Received 15 December 2005; Accepted 13 March 2006

Copyright © 2006 Peng Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was induced in Wistar rats by intraperitoneal injection of CCl4, and thalidomide (10 mg/kg/day or 100 mg/kg/day) was given by intragastric administration for 8 weeks. Liver histopathology and immunohistochemistry were significantly improved and the expressions of ICAM-1, VCAM-1, E-selectin, and TNF-α mRNA and protein were decreased significantly in rats treated with a high dose of thalidomide. Close positive correlation was observed in the expression of the TNF-α mRNA and that of ICAM-1, VCAM-1, and E-selectin mRNA, respectively. These results indicate that thalidomide exerts its effect on the downregulation of adhesion molecules via TNF-α signaling pathway to inhibit liver fibrosis.