Abstract
This study was to evaluate the effects of thalidomide on
expression of adhesion molecules in liver cirrhosis. The cirrhosis
was induced in Wistar rats by intraperitoneal injection of
This study was to evaluate the effects of thalidomide on
expression of adhesion molecules in liver cirrhosis. The cirrhosis
was induced in Wistar rats by intraperitoneal injection of
B Madan, A K Prasad, V S Parmar, and B Ghosh, “1,4-Dihydroxyxanthone modulates the adhesive property of endothelial cells by inhibiting intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin,” Bioorganic and Medicinal Chemistry, vol. 12, no. 6, pp. 1431–1437, 2004.
View at: Google ScholarR Volpes, J J Van den Oord, and V J Desmet, “Immunohistochemical study of adhesion molecules in liver inflammation,” Hepatology, vol. 12, no. 1, pp. 59–65, 1990.
View at: Google ScholarC M Bruno, C Sciacca, D Cilio et al., “Circulating adhesion molecules in patients with virus-related chronic diseases of the liver,” World Journal of Gastroenterology, vol. 11, no. 29, pp. 4566–4569, 2005.
View at: Google ScholarJ A Girón-González, C Martínez-Sierra, C Rodriguez-Ramos et al., “Adhesion molecules as a prognostic marker of liver cirrhosis,” Scandinavian Journal of Gastroenterology, vol. 40, no. 2, pp. 217–224, 2005.
View at: Google ScholarH Yokomori, M Oda, M Ogi et al., “Expression of adhesion molecules on mature cholangiocytes in canal of Hering and bile ductules in wedge biopsy samples of primary biliary cirrhosis,” World Journal of Gastroenterology, vol. 11, no. 28, pp. 4382–4389, 2005.
View at: Google ScholarA Panasiuk, D Prokopowicz, and B Panasiuk, “Monocyte chemotactic protein-1 and soluble adhesion molecules as possible prognostic markers of the efficacy of antiviral treatment in chronic hepatitis C,” World Journal of Gastroenterology, vol. 10, no. 24, pp. 3639–3642, 2004.
View at: Google ScholarJ W Ho, R T Poon, C S Tong, and S T Fan, “Clinical significance of serum vascular cell adhesion molecule-1 levels in patients with hepatocellular carcinoma,” World Journal of Gastroenterology, vol. 10, no. 14, pp. 2014–2018, 2004.
View at: Google ScholarH Yokomori, M Oda, K Yoshimura et al., “Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 protein and messenger RNA in primary biliary cirrhosis,” Internal Medicine, vol. 42, no. 10, pp. 947–954, 2003.
View at: Google ScholarC Pata, A Yazar, E Altintas et al., “Serum levels of intercellular adhesion molecule-1 and nitric oxide in patients with chronic hepatitis related to hepatitis C virus: connection fibrosis,” Hepato-Gastroenterology, vol. 50, no. 51, pp. 794–797, 2003.
View at: Google ScholarA Abdalla, A-A G Sheesha, M Shokeir et al., “Serum intercellular adhesion molecule-I in children with chronic liver disease: relationship to disease activity,” Digestive Diseases and Sciences, vol. 47, no. 6, pp. 1206–1208, 2002.
View at: Google ScholarH Kobayashi, K Horikoshi, L Long, A Yamataka, G J Lane, and T Miyano, “Serum concentration of adhesion molecules in postoperative biliary atresia patients: relationship to disease activity and cirrhosis,” Journal of Pediatric Surgery, vol. 36, no. 8, pp. 1297–1301, 2001.
View at: Google ScholarF Capra, E De Maria, C Lunardi et al., “Serum level of soluble intercellular adhesion molecule 1 in patients with chronic liver disease related to hepatitis C virus: a prognostic marker for responses to interferon treatment,” Journal of Infectious Diseases, vol. 181, no. 2, pp. 425–431, 2000.
View at: Google ScholarF Tacke, P Schöffski, C Trautwein et al., “Plasma P-selectin levels are elevated in patients with chronic liver disease,” Blood Coagulation and Fibrinolysis, vol. 14, no. 4, pp. 319–325, 2003.
View at: Google ScholarM Cervello, L Virruso, G Lipani et al., “Serum concentration of E-selectin in patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma,” Journal of Cancer Research and Clinical Oncology, vol. 126, no. 6, pp. 345–351, 2000.
View at: Google ScholarT Eriksson, S Björkman, and P Höglund, “Clinical pharmacology of thalidomide,” European Journal of Clinical Pharmacology, vol. 57, no. 5, pp. 365–376, 2001.
View at: Google ScholarS V Rajkumar, “Current status of thalidomide in the treatment of cancer,” Oncology (Huntington), vol. 15, no. 7, pp. 867–874, 877–879, 2001.
View at: Google ScholarB Settles, A Stevenson, K Wilson et al., “Down-regulation of cell adhesion molecules LFA-1 and ICAM-1 after in vitro treatment with the anti-TN F- agent thalidomide,” Cellular and Molecular Biology (Noisy-le-Grand), vol. 47, no. 7, pp. 1105–1114, 2001.
View at: Google ScholarC Meierhofer, S Dunzendorfer, and C J Wiedermann, “Theoretical basis for the activity of thalidomide,” BioDrugs, vol. 15, no. 10, pp. 681–703, 2001.
View at: Google ScholarL García, I Hernández, A Sandoval et al., “Pirfenidone effectively reverses experimental liver fibrosis,” Journal of Hepatology, vol. 37, no. 6, pp. 797–805, 2002.
View at: Google ScholarM Pinzani and K Rombouts, “Liver fibrosis: from the bench to clinical targets,” Digestive and Liver Disease, vol. 36, no. 4, pp. 231–242, 2004.
View at: Google ScholarJ Garcia-Bañuelos, F Siller-Lopez, A Miranda, L K Aguilar, E Aguilar-Cordova, and J Armendariz-Borunda, “Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversion,” Gene Therapy, vol. 9, no. 2, pp. 127–134, 2002.
View at: Google ScholarD C Rockey, “Antifibrotic therapy in chronic liver disease,” Clinical Gastroenterology and Hepatology, vol. 3, no. 2, pp. 95–107, 2005.
View at: Google ScholarN Enomoto, Y Takei, M Hirose, T Kitamura, K Ikejima, and N Sato, “Protective effect of thalidomide on endotoxin-induced liver injury,” Alcoholism: Clinical and Experimental Research, vol. 27, no. 8 suppl, pp. 2S–6S, 2003.
View at: Google ScholarA S Austin, Y R Mahida, D Clarke, S D Ryder, and J G Freeman, “A pilot study to investigate the use of oxpentifylline (pentoxifylline) and thalidomide in portal hypertension secondary to alcoholic cirrhosis,” Alimentary Pharmacology and Therapeutics, vol. 19, no. 1, pp. 79–88, 2004.
View at: Google ScholarY Z Patt, M M Hassan, R D Lozano et al., “Thalidomide in the treatment of patients with hepatocellular carcinoma: a phase II trial,” Cancer, vol. 103, no. 4, pp. 749–755, 2005.
View at: Google ScholarC Hsu, J C-H Cheng, and A-L Cheng, “Recent advances in non-surgical treatment for advanced hepatocellular carcinoma,” Journal of the Formosan Medical Association, vol. 103, no. 7, pp. 483–495, 2004.
View at: Google ScholarT-E Wang, C-R Kao, S-C Lin et al., “Salvage therapy for hepatocellular carcinoma with thalidomide,” World Journal of Gastroenterology, vol. 10, no. 5, pp. 649–653, 2004.
View at: Google ScholarA Thiele, R Bang, M Gütschow et al., “Cytokine modulation and suppression of liver injury by a novel analogue of thalidomide,” European Journal of Pharmacology, vol. 453, no. 2-3, pp. 325–334, 2002.
View at: Google ScholarJ-P Raufman and L W Lamps, “Thalidomide-induced normalization of serum ALT levels in a patient with hepatitis C,” American Journal of Gastroenterology, vol. 96, no. 11, pp. 3209–3211, 2001.
View at: Google ScholarP Muriel, E Fernández-Martínez, V Pérez-Álvarez et al., “Thalidomide ameliorates carbon tetrachloride induced cirrhosis in the rat,” European Journal of Gastroenterology and Hepatology, vol. 15, no. 9, pp. 951–957, 2003.
View at: Google ScholarT-S Yeh, Y-P Ho, S-F Huang, J-N Yeh, Y-Y Jan, and M-F Chen, “Thalidomide salvages lethal hepatic necroinflammation and accelerates recovery from cirrhosis in rats,” Journal of Hepatology, vol. 41, no. 4, pp. 606–612, 2004.
View at: Google ScholarP P Simeonova, R M Gallucci, T Hulderman et al., “The role of tumor necrosis factor- in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride,” Toxicology and Applied Pharmacology, vol. 177, no. 2, pp. 112–120, 2001.
View at: Google ScholarK Sudo, Y Yamada, H Moriwaki, K Saito, and M Seishima, “Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice,” Cytokine, vol. 29, no. 5, pp. 236–244, 2005.
View at: Google ScholarR JR Singh, J C Mason, E A Lidington et al., “Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3,” Cardiovascular Research, vol. 67, no. 1, pp. 39–49, 2005.
View at: Google ScholarK Maeda, K Yoshida, I Ichimiya, and M Suzuki, “Dexamethasone inhibits tumor necrosis factor--induced cytokine secretion from spiral ligament fibrocytes,” Hearing Resaerch, vol. 202, no. 1-2, pp. 154–160, 2005.
View at: Google ScholarC-H Woo, J-H Lim, and J-H Kim, “VCAM-1 upregulation via PKC-p38 kinase-linked cascade mediates the TNF--induced leukocyte adhesion and emigration in the lung airway epithelium,” American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 288, no. 2 32-2, pp. L307–L316, 2005.
View at: Google ScholarN Kumagai, K Fukuda, Y Fujitsu, and T Nishida, “Expression of functional ICAM-1 on cultured human keratocytes induced by tumor necrosis factor-,” Japanese Journal of Ophthalmology, vol. 47, no. 2, pp. 134–141, 2003.
View at: Google ScholarM Sasaki, D Ostanin, J W Elrod et al., “TNF--induced endothelial cell adhesion molecule expression is cytochrome P-450 monooxygenase dependent,” American Journal of Physiology - Cell Physiology, vol. 284, no. 2 53-2, pp. C422–C428, 2003.
View at: Google ScholarM Schäefers, C Schmidt, C Vogel, K V Toyka, and C Sommer, “Tumor necrosis factor- (TNF) regulates the expression of ICAM-1 predomonantly through TNF receptor 1 after chronic constriction injury of mouse sciatic nerve,” Acta Neuropathologica (Berlin), vol. 104, no. 2, pp. 197–205, 2002.
View at: Google ScholarN M Dagia, N Harii, A E Meli et al., “Phenyl methimazole inhibits TNF--induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and reduces monocytic cell adhesion to endothelial cells,” Journal of Immunology, vol. 173, no. 3, pp. 2041–2049, 2004.
View at: Google ScholarC H Hang, J-X Shi, J-S Li, W Wu, and X Y Hong, “Concomitant upregulation of nuclear factor-B activity, proinflammatory cytokines and ICAM-1 in the injured brain after cortical contusion trauma in a rat model,” Neurology India, vol. 53, no. 3, pp. 312–317, 2005.
View at: Google ScholarE-W Son, S-J Mo, D-K Rhee, and S Pyo, “Vitamin C blocks TNF--induced NF-B activation and ICAM-1 expression in human neuroblastoma cells,” Archives of Pharmacal Research, vol. 27, no. 10, pp. 1073–1079, 2004.
View at: Google ScholarL Lu, S S Chen, J Q Zhang, F J Ramires, and Y Sun, “Activation of nuclear factor-B and its proinflammatory mediator cascade in the infarcted rat heart,” Biochemical and Biophysical Research Communications, vol. 321, no. 4, pp. 879–885, 2004.
View at: Google ScholarY-H Paik, R F Schwabe, R Bataller, M P Russo, C Jobin, and D A Brenner, “Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells,” Hepatology, vol. 37, no. 5, pp. 1043–1055, 2003.
View at: Google ScholarA L Moreira, E P Sampaio, A Zmuidzinas, P Frindt, K A Smith, and G Kaplan, “Thalidomide exerts its inhibitory action on tumor necrosis factor by enhancing mRNA degradation,” Journal of Experimental Medicine, vol. 177, no. 6, pp. 1675–1680, 1993.
View at: Google ScholarE P Sampaio, M O Hernandez, D S Carvalho, and E N Sarno, “Management of erythema nodosum leprosum by thalidomide: thalidomide analogues inhibit M. leprae-induced TNF production in vitro,” Biomedicine and Pharmacotherapy, vol. 56, no. 1, pp. 13–19, 2002.
View at: Google ScholarJ A Keifer, D C Guttridge, B P Ashburner, and A S Jr Baldwin, “Inhibition of NF-B activity by thalidomide through suppression of I B kinase activity,” Journal of Biological Chemistry, vol. 276, no. 25, pp. 22382–22387, 2001.
View at: Google Scholar