Similar Effects of General and Spinal Anaesthesia on
Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy

Buyukkocak, Unase; Caglayan, Osman; Daphan, Cagatay; Aydinuraz, Kuzey; Saygun, Oral; Kaya, Tahsin; Agalar, Fatih

doi:https://doi.org/10.1155/MI/2006/97257

Mediators of Inflammation

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Volume 2006 | Article ID 097257 | https://doi.org/10.1155/MI/2006/97257

Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy

Unase Buyukkocak,^1,2Osman Caglayan,³Cagatay Daphan,⁴Kuzey Aydinuraz,⁴Oral Saygun,⁴Tahsin Kaya,¹and Fatih Agalar⁴

Received22 Jul 2005

Accepted21 Oct 2005

Published09 Feb 2006

Abstract

Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-α: TNF-α), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to general and spinal anaesthesia groups (n=7). Blood samples were drawn before induction and 24 hours after surgery. Perioperative levels of IL-6, TNF-α, CRP, cortisol, and leptin were comparable among the groups. Twenty four hours after surgery, TNF-α and cortisol did not change; IL-6 and CRP increased significantly in all patients. Significant increase in leptin levels was found in patients undergoing spinal anaesthesia. Except for the increase in leptin levels, there was no significant difference related to the effects of general and spinal anaesthesia.

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Copyright © 2006 Unase Buyukkocak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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